Cystacyclin, a novel microbial metabolite with NGF mimetic activity

Novel sulfur-containing microbial metabolite of primaquine.

Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metabolite as a sulfur-linked dimer was proposed on the basis of spectral and chemi...

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.

R176502, a new bafilolide metabolite with potent antiproliferative activity from a novel Micromonospora species.

During the course of a screening program intended to identify new antiproliferative agents, a new bafilolide metabolite was discovered. R176502 (1) was isolated from the liquid fermentation cultures of a novel Micromonospora species found in African river bottom sediment. It was purified from ethyl acetate extracts using a series of countercurrent chromatographic steps. The structure was determ...

Nerfilin I, a novel microbial metabolite inducing neurite outgrowth of PC12 cells.

A preculture of S. halstedii 2723-SV2 was inoculated into three 50-liters jar fermentors containing 27 liters of the culture mediumconsisting of glycerol 2%, molasses 1%, casein 0.5%, polypepton 0.1% and CaCO3 0.4% (pH 7.0 before sterilization), and fermentation was carried out at 27°C for 24 hours with agitation at 150 rpm and an air flow at 30 liters/minute. Nerfilin I was purified from the s...

Intestinal Microbial and Metabolite Profiling of Mice

1 CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; 7 [email protected] 8 2 Institute of Microbiology, Faculty of Medicine, University of Coimbra, Portugal 9 3 CEDOC, NOVA Medical School, Universidade NOVA de Lisboa, Rua Camara Pestana, no6, 6A, edifício II, 10 piso 3, 1150-082 Lisbon, Portugal 11 4 CICECO-Department of Chemistry, University of Aveiro,...